The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. A nurse or other trained health professional will give you this medicine in a medical facility. It is given through a needle placed into one of your veins.
This medicine is given on a fixed schedule. It may be given after receiving ifosfamide, 4 hours, and 8 hours after each dose of ifosfamide. Drink extra fluids 1 to 2 liters per day so you will pass more urine while you are receiving this medicine. This may help prevent bladder and kidney problems. This medicine needs to be given on a fixed schedule. If you miss a dose or forget to use your medicine, call your doctor or pharmacist for instructions.
It is very important that your doctor check your progress closely while receiving this medicine to make sure this medicine is working properly.
Blood and urine tests will be needed to check for unwanted effects. This medicine is used together with ifosfamide. Ifosfamide can harm your unborn baby while you are pregnant. It may also cause birth defects if the father is receiving it when his sexual partner becomes pregnant. Use an effective form of birth control during treatment with this medicine in combination with ifosfamide and for 6 months after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 3 months after the last dose.
If you think you have become pregnant while receiving this medicine, tell your doctor right away. This can cause bleeding from the bladder and may show up as blood in your urine pee.
This is called haematuria. Mesna helps protect your bladder to prevent irritation and bleeding. Mesna is always given with ifosfamide. Most people who have treatment with cyclophosphamide are not given doses high enough to cause bleeding from the bladder. They will not need to take mesna.
But mesna is given if your treatment involves having high doses of cyclophosphamide. Your doctor can tell you if you are having a high dose of cyclophosphamide. While you are having mesna, your urine pee is tested for signs of blood. If you have blood in your urine, you will be given extra mesna. We explain the most common side effects of this treatment here. We also include some less common side effects. You may get some of the side effects we mention, but you are unlikely to get all of them.
It is often difficult to know which side effects may be caused by mesna and which ones may be caused by the chemotherapy. Always tell your doctor or nurse about the side effects you have. Your doctor can give you drugs to help control some side effects. It is important to take them exactly as your nurse or pharmacist explains. This means they will be more likely to work for you. Your nurse will give you advice about managing your side effects.
After your treatment is over, most side effects start to improve. Your nurse will give you telephone numbers for the hospital. If you feel unwell or need advice, you can call them at any time of the day or night.
Save these numbers in your phone or keep them somewhere safe. Some cancer treatments can cause severe side effects. Rarely, these may be life-threatening. Your cancer doctor or nurse can explain the risk of these side effects to you. We cannot list every side effect for this treatment.
There are some rare side effects that are not listed. You can visit the electronic Medicines Compendium eMC for more detailed information. Rarely, mesna may cause an allergic reaction. Your nurse will check you for this. If you have a reaction, they will treat it quickly. Allergic reactions are most common with the first few doses. A reaction is usually mild. Rarely, it can be more severe.
Tell your nurse straight away if you notice any of these symptoms. If you develop any of these symptoms or feel unwell when you are at home, contact the hospital straight away on the number you have been given.
They can give you advice. You may feel sick. Your doctor will give you anti-sickness drugs to help prevent or control sickness. Take the drugs exactly as your nurse or pharmacist tells you. It is easier to prevent sickness than to treat it after it has started. Periodic blood work to monitor your complete blood count CBC as well as the function of other organs such as your kidneys and liver will also be ordered by your doctor. Your urine may be checked prior to starting treatment and periodically during treatment to check for microscopic blood in the urine.
Mesna is classified as a chemoprotective agent. Chemoprotective agents are drugs that are used with certain types of chemotherapy to protect the body from or minimize the side effects of the chemotherapy. These medications do not eliminate side effects in general.
Rather, they protect the body from some of the potentially serious side effects. These drugs also have side effects of their own so they are used only with specific types of chemotherapy or when the benefit clearly is greater than the risk. Mesna is converted to an inactive form in the blood, then as it is circulated through the kidneys it is reactivated. The reactivated mesna works by interacting with metabolites substances produced by breakdown of a drug in the body. Two specific chemotherapies, ifosfomide and cyclophosphamide given in high doses when broken down produce a metabolite acrolein.
This metabolite is toxic to the bladder.
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